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Yttrium 90 Microspheres Education and Support

When The Improbable
 Is Possible

Papers - Clinical Trial Outcomes

Colorectal Cancer

Sharma R, van Hazel G, Morgan B et al. Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy. Journal of Clinical Oncology 2007; 25: 1099-1106

Mancini R, Carpanese L, Sciuto R et al. A multicentric phase II clinical trial on intra-arterial hepatic radiotherapy with yttrium 90 SIR-Spheres in unresectable, colorectal liver metastases refractory to i.v. chemotherapy: Preliminary results on toxicity and response rates. In vivo 2006; 20: 711-714.

van Hazel G, Blackwell A, Anderson J et al. Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer. Journal of Surgical Oncology 2004: 88: 78-85.

Gray B, van Hazel G, Hope M et al. Randomised trial of SIR-Spheres plus chemotherapy vs chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Annals of Oncology 2001; 12: 1711-1720.

Hepatocellular Carcinoma

Lau W, Leung W, Ho S et al. Treatment of inoperable hepatocellular carcinoma with intra-hepatic arterial yttrium-90 microspheres: a phase I and II study. British Journal of Cancer 1994: 70: 994-999.